The show is set in the Milky Way Galaxy, roughly during the 2260s. The crew is headed by Captain James T. Kirk (William Shatner), science officer Spock (Leonard Nimoy), and chief medical officer Dr. Leonard McCoy (DeForest Kelley).
The series was produced from 1966-1967 by Desilu Productions and by Paramount Television from 1968-1969. Star Trek aired on NBC from September 8, 1966, to June 3, 1969. Although this television series had the title of Star Trek, it later acquired the retronym of Star Trek: The Original Series to distinguish the show within the media franchise that it began.
The show had a major influence on popular culture, and it became a cult classic in syndication during the 1970s. It eventually spawned a franchise that consisted of five additional TV series, 12 theatrical films, and numerous books, games, toys, and other products.