In addition to fiction, each issue contained an editorial, articles on science, and other features related to the science of the day.
The first five issues were issued in a slick, folio format; the last two in a large, pulp format. All issues had 64 pages.
Genre historian Donald H. Tuck wrote that this was "probably the best looking sf magazine ever produced." Despite its appearance, Science-Fiction Plus was not a financial success.
A recent critical history of the magazine by Jon D. Swartz was published in the January, 2017 issue of The National Fantasy Fan (Volume 76, Number 1).